SLU-PP-332 – 60 capsules – metabolic & mitochondria boost

SLU-PP-332 – 60 capsules

 

What is SLU-PP-332?

• SLU-PP-332 is a synthetic REV-ERB agonist developed by researchers at Saint Louis University (SLU).

• It belongs to a class of compounds that modulate the circadian clock and have downstream effects on lipid metabolism, glucose homeostasis, and mitochondrial function.

• It builds upon earlier REV-ERB agonists like SR9009 and SR9011, with improved potency and selectivity in certain studies.

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🌟 Key Benefits and Potential Effects (based on preclinical studies):

1. 🧬 Circadian Rhythm Modulation

• Enhances the function of core clock genes (e.g., BMAL1 suppression) via REV-ERB activation.

• Could be beneficial for circadian misalignment, jet lag, or shift work disorders.

2. 🔥 Enhanced Mitochondrial Activity & Fat Burning

• Increases mitochondrial biogenesis and oxidative capacity in skeletal muscle.

• Leads to increased energy expenditure without requiring more physical activity.

• May simulate some of the effects of exercise at a molecular level (often dubbed an “exercise mimetic”).

3. 🩸 Improved Lipid and Glucose Metabolism

• Reduces plasma triglycerides, cholesterol, and blood glucose levels in obese mouse models.

• Improves insulin sensitivity, making it potentially relevant for type 2 diabetes or metabolic syndrome.

4. 🧠 Neuroprotective and Anti-inflammatory Effects

• REV-ERB activity is linked to suppression of pro-inflammatory cytokines (e.g., IL-6, TNF-α).

• May have protective roles in neurodegenerative diseases and neuroinflammation, though this is early-stage research.

5. 💪 Muscle and Endurance Support

• Promotes lean muscle preservation and reduces fat accumulation in mice.

• Improves exercise capacity and endurance markers in some rodent studies.

Summary

SLU-PP-332 is a potent REV-ERB agonist with promise in metabolic regulation, circadian health, and energy metabolism. It may enhance fat burning, improve blood sugar levels, and support mitochondrial health—acting like an “exercise in a pill.” However, until human trials are done, its safety and effectiveness remain theoretical.